Publications and Funding

Recent Publications

Anderson, N.C., Chen, C.Y., Grabel, L. (2016). Hedgehog Promotes Production of Inhibitory Interneurons in Vivo and in Vitro from Pluripotent Stem Cells. J. Dev. Biol. 2016, 4, 26 doi:10.3390/jdb4030026.

Chen, C.Y., Plocik, A., Anderson, N.C., Moakley, D., Boyi, T., Dundes, C., Lassiter, C., Graveley, B.R., Grabel, L. (2016). Transcriptome and in Vitro Differentiation Profile of Human Embryonic Stem Cell Derived NKX2.1-Positive Neural Progenitors. Stem Cell Rev. and Rep., DOI 10.1007/s12015-016-9676-2.

Lassiter, C.M., Gal, J.S., Becker, S., Hartman, N.W., Grabel, L. (2016). Embryonic stem cell-derived neural progenitors transplanted to the hippocampus migrate on host vasculature. Stem Cell Res. 2016, 16( 3): 579-588.

Naegele, J., Grabel, L., and Aaron, G. (2015).  Immature Interneurons Create a Lasting Impression (commentary on recent literature using transplantation approaches in epileptic mice).  Epilepsy Curr. 2015 May-Jun;15(3):140-2.

Banda, E., McKinsey, A., Germain, N., Carter, J., Anderson, N.C. and Grabel, L. (2015).  Cell polarity and neurogenesis in embryonic stem cell-derived neural rosettes.  Stem Cells and Development.  2015 April 15;24(8):1022-33.

Banda, E., Grabel, L. (2014).  Directed differentiation of human embryonic stem cells into neural progenitors.  Methods in Molecular Biology.  2016;1307:289-98

Germain, N.D., Banda, E.C., Becker, S., Naegele, J.R., Grabel, L.B. (2013).  Derivation and isolation of NKX2.1-positive basal forebrain progenitors from human embryonic stem cells.  Stem Cells and Development.  2013 May 15;22(10):1477-89.

Germain, N., Hartman, N., Cai, C., Becker, S., Naegele, J., Grabel, L. (2011). Teratocarcinoma formation in embryonic stem cell-derived neural progenitor hippocampal transplants.  Cell Transplantation.  2012;21(8):1603-11.

Grabel, L. (2012).  Developmental origin of neural stem cells: the glial cell that could.  Stem Cell.  2012 Jun;8(2):577-85.  Review.

Maisano, X., Litvina, E., Tagliatela, S., Aaron, G.B., Grabel, L.B., Naegele, J.R. (2012).  Differentiation and functional incorporation of embryonic stem cell-derived GABAergic interneurons in the dentate gyrus of mice with temporal lobe epilepsy.  Journal of Neuroscience.  2012 Jan 4;32(1):46-61.

Grabel, L (2012).  Prospects for pluripotent stem cell therapies: into the clinic and back to the bench.  Journal of Cellular Biochemistry.  2012 Feb;113(2):381-7.  Review.

Hartman, N., Carpentino, J., LaMonica, K., Mor, D., Naegele, J., Grabel, L. (2010). CXCL12-mediated guidance of migrating embryonic stem cell-derived neural progenitors transplanted into the hippocampus.  PLoS One.  2010 Dec 31;5(12):e15856.

Germain, N., Banda, E., Grabel, L. (2010).  Embryonic stem cell neurogenesis and neural specification.  Journal of Cellular Biochemistry.  2010 Oct 15;111(3):535-42.

Ammon, N., Hartman, N., Grabel, L. (2010).  Directing differentiation of embryonic stem cells into distinct neuronal subtypes.  In  H. Ulrich Editor, Perspectives of Stem Cells: From tools for studying mechanisms of neuronal differentiation towards therapy (pp. 97-114). Dordrecht: Springer Press.

Hartman, N., Grabel, L., Naegele, J.  (2011).  Migration of transplanted neural stem cells in experimental models of neurodegenerative diseases.   K. Appasani Editor, Stem Cells and Regenerative Medicine: From Molecular Biology to Tissue Engineering (pp 315-336).  New York: Humana/Springer Press.

LaMonica, K., Bass, M., Grabel, L.  (2009).  The planar cell polarity pathway directs parietal endoderm migration.  Developmental Biology.  2009 Jun 1;330(1):44-53.

Cai, C., Thorne, J., Grabel, L. (2008).  Hedgehog serves as a mitogen and survival factor during embryonic stem cell neurogenesis.  Stem Cells.  2008 May;26(5):1097-108.

Cai, C., and Grabel, L. (2007).  Directing the differentiation of embryonic stem cells to neural stem cells.  Developmental Dynamics.  2007 Dec;236(12):3255-66

Carpentino, J., Hartman, N., Grabel, L., and Naegele, J.  (2007).  Region-specific differentiation of ES-derived neural progenitor transplants into the adult mouse hippocampus following seizures.   Journal of Neuroscience Research.  2008 Feb 15;86(3):512-24.

Gruen, Lori, Laura Grabel, and Peter Singer.  Stem Cell Research: The Ethical Issues. Oxford: Blacking, 2007. Print.

Gruen, L., and Grabel, L. (2006).  Concise Review: Scientific and ethical roadblocks to human embryonic stem cell therapy.  Stem Cells.  2006 Oct;24(10):2162-9.

Mills, E., LaMonica, K., Hong, T., Pagliaruli, T., Mulrooney, J. and Grabel, L.  (2005)  Roles for Rho/Rock and vinculin in parietal endoderm migration.  Cell Communication and Adhesion.  2005 Jan-Apr;12(1-2):9-22.

Hong, T. and Grabel, L. (2006)  Migration of F9 parietal endoderm is regulated by the ERK pathway.  Journal of Cellular Biochemistry.  2006 Apr 15;97(6):1339-49.

Byrd, N., Grabel, L. (2004).  Hedgehog signaling in murine vasculogenesis and angiogenesis.  Trends in Cardiovascular Medicine.  2004 Nov;14(8):308-13. Review.

Maye, P., Becker, S., Siemen, H., Thorne, J., Byrd, N., Carpentino, J., and Grabel, L. (2004).  Hedgehog signaling is required for the differentiation of ES cells into neuroectoderm.  Developmental Biology.  2004 Jan 1;265: 276-290.

To view more publications, view PubMed listing.


Our Lab is currently funded by:

The Connecticut Stem Cell Initiative

The National Institutes of Health

CURE (Citizens United for Research in Epilepsy)